Crosslinking Reagents
Medchemexpress LLC Bis(3-sulfo-N-succinimidyl) suberate disodium salt | 127634-19-9 | MFCD00054982 | 98.0% | 572.43 | C16H18N2Na2O14S2 | 10 MG
BS3 Crosslinker disodium is a water-soluble, non-cleavable, homobifunctional amine-reactive crosslinker used to form stable amide bonds between primary amines. It is commonly used for antibody-drug conjugate synthesis, protein crosslinking, and bioconjugation workflows. CAS 127634-19-9; molecular weight 572.43; typical purity 98%.
- Water-soluble homobifunctional crosslinker for amine-to-amine coupling.
- Non-cleavable sulfo-NHS ester chemistry produces stable amide bonds.
- Membrane-impermeable, suitable for surface and extracellular protein crosslinking.
- Widely used in antibody-drug conjugate design and general bioconjugation.
- Provided as a solid powder with high stated purity for research use only.
- Available in small-scale package sizes for laboratory experiments.
TARGETMOL CHEMICALS INC SULFO-SMCC SODIUM 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sulfo-SMCC sodium is a commonly used hetero-bifunctional non-cleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups respectively. purity: 99%
Cayman Chemical Val-CIt-PAB-OH 50mg
A peptide linker molecule; cleaved by cathepsin B; has been used in the synthesis of ADCs containing KGP05 or MMAD, as well as α-galactosylceramide or folic acid conjugates that target peptide antigens to natural killer T cells or CRM1 inhibitors to cancer cells, respectively
Abcam BS3 crosslinker, primary amine reactive crosslinker, 250MG
MW 572.4 Da, Purity >90%. Homobifunctional, membrane-impermeable primary amine reactive crosslinker. Crosslinks cell surface proteins. Facilitates structural characterization of proteins with mass spectrometry.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Hexanoic acid, 6-azido-, 2,5-dioxo-1-pyrrolidinyl ester | 866363-70-4 | MFCD25968077 | 98.0% | 254.24 g/mol | C10H14N4O4 | 250 MG
N3-C5-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker and click chemistry reagent that contains an azide group and an N-hydroxysuccinimide (NHS) ester for efficient amine coupling. It is used to introduce azide handles for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and to activate carboxyl groups for conjugation to biomolecules.
- Noncleavable ADC linker suitable for bioconjugation
- Contains azide group for click chemistry (CuAAC)
- NHS ester functional group for coupling to primary amines
- Purity ≥98.0%
- Supplied as a colorless to light yellow liquid; soluble in DMSO
- Molecular weight 254.24 g/mol; formula C10H14N4O4
- Storage: pure form -20°C; in solvent short-term at -20°C to -80°C
eMolecules TargetMol DSG Crosslinker 50mg 726061664 T15171 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
TargetMol DSG Crosslinker 50mg 726061664 T15171 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
Cayman Chemical Sulfo-SMCCsodIum salt 100mg
A water-soluble protein cross-linking reagent; has been used to conjugate anti-PD-L1 antibodies to the surface of platelets and Golgi-targeting peptides to platelet microparticle-mimetic nanoplatforms
Cayman Chemical 1 3-DImethylurIc AcId 50mg
An active metabolite of caffeine and theophylline; scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 77% in isolated human erythrocyte membranes at 500 µM; induces contractions in isolated rabbit duodenal, jejunal, and ileal preparations; induces relaxation in isolated rabbit ascending colon preparations; intracerebral administration induces clonic convulsions in mice (ED50 = 360 nmol/animal); has been found in urinary caliculi
Medchemexpress LLC Peg4-spdp | 1305053-43-3 | 488.57 g/mol | C20H28N2O8S2 | 250 MG
PEG4-SPDP is a cleavable polyethylene glycol (PEG4) spacer variant of the SPDP crosslinker used as an ADC linker and general bioconjugation reagent. It features an N-hydroxysuccinimide (NHS) ester for amine coupling and a 2-pyridyldithiol group for thiol coupling, providing a reducible disulfide linkage for controlled payload release in reducing environments.
- Cleavable disulfide linker for controlled payload release in reducing environments.
- Amine-reactive NHS ester for conjugation to lysine residues.
- 2-pyridyldithiol group for thiol coupling and disulfide bond formation.
- Suitable for antibody-drug conjugates and protein crosslinking.
- Stable as a solid at -20°C; store solutions at lower temperatures for short-term use.
Medchemexpress LLC BS3 crosslinker | 82436-77-9 | MFCD01861948 | 99.8% | 528.47 | C16H20N2O14S2 | 100 MG
BS3 Crosslinker is a water-soluble, homobifunctional N-hydroxysuccinimide (NHS)-ester crosslinker used to covalently link primary amines in proteins and small molecules. It provides a non-cleavable eight-carbon spacer arm appropriate for antibody-drug conjugate synthesis, bioconjugation, and protein crosslinking workflows. The reagent offers high purity, documented solubility in common solvents, and manufacturer guidance for storage and handling to preserve stability.
- Non-cleavable homobifunctional NHS-ester crosslinker.
- Water soluble, suitable for aqueous bioconjugation.
- Reacts specifically with primary amines to form stable amide bonds.
- Eight-carbon spacer arm for controlled linker length.
- High purity (99.84%) for reproducible results.
- Soluble in DMSO and water; ultrasonic agitation recommended.
- Storage recommendations included to preserve stability.
eMolecules TargetMol DSG Crosslinker 10mg 726061662 T15171 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
TargetMol DSG Crosslinker 10mg 726061662 T15171 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
Cayman Chemical Sulfo-SMCCsodIum salt 50mg
A water-soluble protein cross-linking reagent; has been used to conjugate anti-PD-L1 antibodies to the surface of platelets and Golgi-targeting peptides to platelet microparticle-mimetic nanoplatforms